第7回　化学センサ研究発表会


September 25-26, 1988
Saitama University

10
酸化チタン酸素電極を用いたグルコースセンサの特性

木村正美・池田章一郎・伊藤　要・大倉國利*・中尾昭公*・高木　弘*・近藤達平*

名工大・名大医*

DEVELOPMENT OF A NEEDLE-TYPE GLUCOSE SENSOR BASED ON TITANIUM DIOXIDE OXYGEN ELECTRODES

Shoichiro IKEDA, Masami KIMURA, Kaname ITO, Kunitoshi OHKURA*, Akimasa NAKAO*, Hiroshi TAKAGI*　and Tatsuhei KONDO*

Department of Applied Chemistry, Nagoya Institute of Technology
Gokiso-cho Showa-ku, Nagaya 466, Japan
*Second Department of Surgery, Nagoya University School of Medicine
65 Tsurumai-cho Showa-ku, Nagoya 466, Japan

A new needle-type glucose sensor has been developed using an oxygen electrode based on a new concept which is composed of a Ti wire whose surface was anodically oxidized to form a thin oxide layer, and works well as an oxygen sensor with an applied potential of -0.8 V vs. a Ag/AgCl reference/counter electrode. Glucose oxidase was immobilized on the oxide layer treated with 3-aminopropyltriethoxysilane using glutaraldehyde and bovine serum albumin. Several surface analyses were employed to investigate the surface characteristics of the sensor. This sensor responds glucose up to 30 mg/dl without a semipermeable membrane. By 5 times dip-coating of cellulose acetate, the sensor responds up to 700 mg/dl. In vivo test using a normal dog, the sensor responds the blood glucose levels, although improvements in the response time and stability are still required.